2. Natural Products
  3. Antibiotics
  4. Polyether Antibiotics

Polyether Antibiotics

Structural features of Polyether antibiotics include an exterior alkyl backbone that confers their lipophilic characteristics and an oxygen-rich internal cavity that can bind metal ions. They affect the targeted cells by changing the permeability of cellular membranes to cationic metal species that lead to changes in Na+/K+ gradient and an increase in the osmotic pressure inside the cell, causing swelling, vacuolization, and ultimately death of the bacterial cell. These antibiotics show a broad spectrum of bioactivity including antibacterial (both for drug-sensitive and drug-resistant bacteria), antifungal, anti-parasitic, antiviral and tumor cell cytotoxicity.

Polyether Antibiotics (15):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6687
    Calcimycin 52665-69-7 99.12%
    Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy.
    Calcimycin
  • HY-100528
    Nanchangmycin 65101-87-3 99.27%
    Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
    Nanchangmycin
  • HY-100528A
    Dianemycin 35865-33-9 98.29%
    Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
    Dianemycin
  • HY-N8310
    Tunicamycin A1 66081-37-6
    Tunicamycin A1 (Tunicamycin 14:1; Tunicamycin II; Tunicamycin C) is an antibiotic. Tunicamycin A1 exhibits antibacterial activity against a variety of bacterial. Tunicamycin A1 can be used in studies related to bacterial infections.
    Tunicamycin A1
  • HY-N18360
    Tunicamycin X 66081-38-7
    Tunicamycin X (Tunicamycin 17:1) is a nucleoside Antibiotic. Tunicamycin X is isolated from Streptomyces xinghaiensis SCSIO S15077. Tunicamycin X acts as a growth inhibitor against bacteria and fungi. Tunicamycin X inhibits the growth of Bacillus thuringiensis strains. Tunicamycin X inhibits the growth of Candida albicans strains.
    Tunicamycin X
  • HY-100528R
    Nanchangmycin (Standard) 65101-87-3
    Nanchangmycin (Standard) is the analytical standard of Nanchangmycin. This product is intended for research and analytical applications. Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2].
    Nanchangmycin (Standard)
  • HY-100528AR
    Dianemycin (Standard) 35865-33-9
    4-Methoxycinnamic acid (Standard) is the analytical standard of 4-Methoxycinnamic acid. This product is intended for research and analytical applications. 4-Methoxycinnamic acid is detected as natural phenylpropanoid in A. preissii.
    Dianemycin (Standard)
  • HY-N7071
    Maduramicin 79356-08-4
    Maduramicin (Maduramycin) is isolated from the actinomycete Actinomadura rubra. Maduramicin is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection. Maduramicin induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.
    Maduramicin
  • HY-112225
    Narasin sodium 58331-17-2
    Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin sodium has antimicrobial and anticancer activity.
    Narasin sodium
  • HY-N6687A
    Calcimycin hemicalcium salt 59450-89-4
    Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy.
    Calcimycin hemicalcium salt
  • HY-N14311
    Noboritomycins A 68508-45-2
    Noboritomycins A is a polyether antibiotic. Noboritomycins A has anti-Gram-positive bacterial effect. Noboritomycins A has weak anti-coccidial effect.
    Noboritomycins A
  • HY-N15069
    4'-O-Demethyldianemycin 80118-77-0
    4'-O-Demethyldianemycin (TM-531B) is a polyether antibiotic found in Streptomyces hygroscopicus TM-531. Activity against Gram-positive bacteria.
    4'-O-Demethyldianemycin
  • HY-N13988
    Abierixin 100634-16-0
    Abierixin has good anti-coccidial activity and weak antibacterial and ionophore activity.
    Abierixin
  • HY-N14312
    Noboritomycins B 68508-46-3
    Noboritomycins B is a polyether antibiotic. Noboritomycins B has anti-Gram-positive bacterial effect. Noboritomycins B has weak anti-coccidial effect.
    Noboritomycins B
  • HY-N6687R
    Calcimycin (Standard) 52665-69-7
    Calcimycin (Standard) is the analytical standard of Calcimycin. This product is used for research and analytical applications. Calcimycin is an antibiotic and a unique divalent cation ionophore, such as calcium ions and magnesium ions. Calcimycin induces Ca2+ -dependent cell death by increasing the intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and uncouples the oxidative phosphorylation (OXPHOS) of mammalian cells, inducing apoptosis and autophagy.
    Calcimycin (Standard)